The prefix “re,” to anew again, suggests the motion of “undoing.” In this single unit of language lies the most important approach that we – as leaders, as organizations, as nations, and as humans – can employ as we determine strategies for the distant and immediate future. In this issue, we explore how “re” is the only sound approach when, despite loud evidence and urgent calls for attention, our wickedest challenges are not being adequately addressed. Our systems have proven durable but not effectual or adaptable. Traditional management thinking has left organizations ill-equipped for a world where innovation is required for survival. Governments are dysfunctional and policy can’t keep pace with change – technological, social, or climate. We need to rethink, reimagine, reset.