Reinvention is core to change and transition. We see it in our relationships, our careers, and our other pursuits. Organizations depend on it to survive disruptions small and big, from yearly growth to extreme competition. Reinvention is woven into all aspects of human life – the social, economic, political, and environmental. Yes, we need reinvention. In this issue, MISC looks at the breakpoints, origins, and processes of reinvention.